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Synthetic approaches to the furanocembrane family of natural products, e.g. lophotoxins, pukalides, bipinnatins, based on: i) an intramolecular cyclisation of an alpha,beta-unsaturated acyl radical intermediate into a conjugated enone, and ii) an intramolecular Stille coupling reaction involving a 2-stannylfuran and a vinyl iodide, are described. A total synthesis of bis-deoxylophotoxin , the probable biological precursor to the neurotoxin lophotoxin, isolated from species of the Pacific sea whip Lophogorgia, is then presented.


Manuel Cases, Felix Gonzalez-Lopez de Turiso, Maria S Hadjisoteriou, Gerald Pattenden. Synthetic studies towards furanocembrane diterpenes. A total synthesis of bis-deoxylophotoxin. Organic & biomolecular chemistry. 2005 Aug 7;3(15):2786-804

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PMID: 16032357

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