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reaction: see text] Densely substituted styryl sulfone 20 is shown to undergo double annulation with phthalide 21 to give, in one-pot operation and in excellent yield, the benzonaphthopyranone scaffold 22 of gilvocarcins.

Citation

Asit Patra, Pallab Pahari, Sutapa Ray, Dipakranjan Mal. A brief and convergent synthetic route to defucogilvocarcin M chromophore: the formal synthesis of WS-5995 A and C. The Journal of organic chemistry. 2005 Oct 28;70(22):9017-20

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PMID: 16238342

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