1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: new antibiotics from marine-derived streptomycetes.

Ines Kock, Rajendra P Maskey, M A Farooq Biabani, Elisabeth Helmke, Hartmut Laatsch

Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammanstrasse 2, D-37077 Göttingen, Germany.

The Journal of antibiotics 2005 Aug

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Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin (3a) and tetracenomycin (4), and a further member of the rare resistomycin class, the weakly antibiotically active 1-hydroxy-1-norresistomycin (2). From a related marine strain B4842, 1 and resistoflavin methyl ether (3b) have been isolated. The formation of 2 is of interest from a biosynthetic point of view.

Citation

Ines Kock, Rajendra P Maskey, M A Farooq Biabani, Elisabeth Helmke, Hartmut Laatsch. 1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: new antibiotics from marine-derived streptomycetes. The Journal of antibiotics. 2005 Aug;58(8):530-4