Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin.

Yves Blériot, Dirk Gretzke, Thomas M Krülle, Terry D Butters, Raymond A Dwek, Robert J Nash, Naoki Asano, George W J Fleet

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. yves.bleriot@chimie.ens.fr

Carbohydrate research 2005 Dec 30

filter terms:

1,6-Dideoxygalactostatin, the mirror image of 1-deoxy-L-fuconojirimycin, was efficiently prepared from 2,3-O-isopropylidene-L-lyxonolactone in four steps and evaluated as a glycosidase inhibitor.

Citation

Yves Blériot, Dirk Gretzke, Thomas M Krülle, Terry D Butters, Raymond A Dwek, Robert J Nash, Naoki Asano, George W J Fleet. Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin. Carbohydrate research. 2005 Dec 30;340(18):2713-8