CaMKII structure--an elegant design.

Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. hunter@salk.edu

Cell 2005 Dec 2

filter terms:

Crystal structures of protein kinases continue to reveal new mechanisms for the regulation of catalytic activity of these enzymes. In this issue of Cell, Rosenberg et al. (2005) report the structure of the catalytic and regulatory domains of CaMKII, a protein kinase important in the cellular response to changes in intracellular calc ium ion concentration. This study provides new mechanistic insights into the workings of this finely tuned molecular machine.