Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature.

Benign metastasizing leiomyoma (BML) is an unusual condition typically treated by surgical resection and hormonal therapy. A 37-year-old woman presented with dyspnea 6 years after uterine myomectomy. Computed tomographic scans showed pelvic and right-sided lung masses. Total abdominal hysterectomy and right salpingo-oophorectomy revealed only leiomyomas and benign ovarian cysts. Thoracotomy revealed multiple nodules consistent with leiomyomas. Estrogen and progesterone receptors on lung and uterine tissue were positive. A 21- x 18-mm residual area of neoplasm in the lung completely resolved 3 months after treatment with megestrol. The patient remains free of disease 3 years after lung resection. We present a rare case of BML in which the lung neoplasm responded to megestrol alone in the setting of intact ovarian function.

Citation

G K Wentling, B-U Sevin, X J Geiger, M D Bridges. Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2005 Nov-Dec;15(6):1213-7

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PMID: 16343217

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