Protein phosphatase inhibitor-1 (PPI-1) has protective activities in stress conditions in E. coli.

Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon 443-749, South Korea. doohunkim@ajou.ac.kr

International journal of biological macromolecules 2006 Feb 28

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Protein phosphatase inhibitor-1 (PPI-1) is a major inhibitor of protein phosphatase 1 (PP1), which regulates signal transduction in many eukaryotic cellular processes. Biophysical studies have shown that PPI-1 has a large Stokes radius and is heat stable, suggesting that it lacks extensive secondary structures. The unfolded structure of PPI-1 may enable it to interact with many proteins or ligands during stress conditions. Here we show that PPI-1 can act as a protective molecule, inhibiting protein aggregation and guarding E. coli cells against various stresses. Therefore, PPI-1 seems to have a physiological function as a protective molecule as well as regulator of protein serine/threonine phosphatases.

Citation

Thomas Doohun Kim. Protein phosphatase inhibitor-1 (PPI-1) has protective activities in stress conditions in E. coli. International journal of biological macromolecules. 2006 Feb 28;38(1):70-6