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Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.

Louis de Léséleuc, François Denis

INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval (QC), Canada H7V 1B7.

Experimental cell research 2006 May 15


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    The orphan nuclear receptor Nur77 has been implicated in both growth and apoptosis, and its function and activity can be modulated by cellular redistribution. Green fluorescent protein-tagged Nur77 was used to evaluate the role of Nur77 intracellular redistribution in response to genotoxic stress. Selected DNA damaging agents and transcription inhibition lead to rapid redistribution of Nur77 into nuclear structures distinct from conventional nuclear bodies. These nuclear bodies formed transiently were tightly bound to the nuclear matrix and conditions that lead to their appearance were associated with Nur77 transcriptional inhibition. The formation of Nur77 nuclear bodies might be involved in programmed cell death modulation upon exposure to DNA damaging agents that inhibit transcription by sequestrating this proapoptotic factor in dense nuclear structures.

    Citation

    Louis de Léséleuc, François Denis. Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest. Experimental cell research. 2006 May 15;312(9):1507-13

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    PMID: 16480977

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