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Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.

Citation

Yolanda S Andersen, Frances D Gillin, Lars Eckmann. Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp. Infection and immunity. 2006 Apr;74(4):2473-6

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PMID: 16552082

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