Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp.

Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.

Citation

Yolanda S Andersen, Frances D Gillin, Lars Eckmann. Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp. Infection and immunity. 2006 Apr;74(4):2473-6

Mesh Tags

Substances

PMID: 16552082

search → result