Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.

Adinarayana Gorajana, M Venkatesan, Saisha Vinjamuri, Bapiraju V V S N Kurada, Sujatha Peela, Premkumar Jangam, Ellaiah Poluri, Axel Zeeck

School of Pharmacy, International Medical University, Sesama Center, Plaza, Komanwel, Bukit jalil, 57000 Kuala Lumpur, Malaysia. glknarayana@yahoo.com

Microbiological research 2007

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In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN1/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial activities against Gram-positive and Gram-negative bacteria.

Citation

Adinarayana Gorajana, M Venkatesan, Saisha Vinjamuri, Bapiraju V V S N Kurada, Sujatha Peela, Premkumar Jangam, Ellaiah Poluri, Axel Zeeck. Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7. Microbiological research. 2007;162(4):322-7