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Regulation of gene expression by transcription factors touches all aspects of human biology and often induces extreme phenotypes. Its external, precise control by small organic molecules represents a challenge in chemistry and biology. Here, we summarize recent progress in the field, together with contributions from our laboratory. Small-molecule modulators of transcription, including small-molecule transcription factors could find their use in basic biological studies and therapeutic intervention.


Dongju Jung, Yongmun Choi, Motonari Uesugi. Small organic molecules that modulate gene transcription. Drug discovery today. 2006 May;11(9-10):452-7

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PMID: 16635809

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