Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models.

Katalin Sándor, Krisztián Elekes, Arpád Szabó, Erika Pintér, Mia Engström, Siegfried Wurster, János Szolcsányi, Zsuzsanna Helyes

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs-7624 Szigeti str. 12, Hungary.

European journal of pharmacology 2006 Jun 6

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Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst4). In the present study, the antinociceptive effects of a novel somatostatin sst4 receptor selective peptidomimetic compound, J-2156 (1-100 microg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy.

Citation

Katalin Sándor, Krisztián Elekes, Arpád Szabó, Erika Pintér, Mia Engström, Siegfried Wurster, János Szolcsányi, Zsuzsanna Helyes. Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models. European journal of pharmacology. 2006 Jun 6;539(1-2):71-5