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The authors report a case of chronic lymphatic leukemia occurring four years after the onset of pernicious anemia. Multiple immunological abnormalities were detected. Hemolytic anemia with auto-antibodies and anti-thyroglobulin antibodies. Anti-intrinsic factor antibodies of type 1 were found but disappeared later. This case, the 9 th in the world literature, emphasizes the links between pernicious anemia, an auto-immune disease, and malignant disorders of the lymphatic and immune systems.


R Zittoun, J Zittoun, J Bousser. Biermer's anemia with chronic lymphoid leukemia and hemolysis with autoantibodies]. La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris. 1975 Jan 20;51(4):233-5

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PMID: 167442

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