Antigen measurement and biomechanical characteristics of the inbred-line Banna mini-pig acellular bone matrix].

Shiwu Dong, Dajun Ying, Chuhong Zhu, Jiansen Sun, Wei Zhang, Yangzhi Zeng

The Key Lab of Biomechanics under the Ministry of Education, Department of Anatomy, The Third Military Medical University, Chongqing 400038, China.

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 2006 Jun

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In this study, we prepared the acellular bone matrix of the inbred-line Banna mini-pig by using tissue engineering method and evaluated its possible application in bone tissue engineering. Histological analysis, xenoantigen expression and biomechanical measurement were performed on the matrix. HE staining and scanning electron microscopy showed the cellular components were almost removed. Immunohischemical result demonstrated that the xenoantigen, alpha-gal,was also eliminated. There was no statistically significant difference between the acellular bone matrix group and control group. The acellular bone matrix can provide appropriate space structure and strength for grafts. In conclusion, our data suggest that acellular bone matrix is a new kind of ideal bone scaffold material.

Citation

Shiwu Dong, Dajun Ying, Chuhong Zhu, Jiansen Sun, Wei Zhang, Yangzhi Zeng. Antigen measurement and biomechanical characteristics of the inbred-line Banna mini-pig acellular bone matrix]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 2006 Jun;23(3):551-5