Saponins of polygalacic acid type from Platycodon grandiflorum].

Wen-wei Fu, Wen-bin Hou, De-qiang Dou, Hui-ming Hua, Mao-hua Gui, Rui Fu, Ying-jie Chen, Yue-hu Pei

School of Traditional Chinese Material Medica, Shenyang Pharmaceutical University, China.

Yao xue xue bao = Acta pharmaceutica Sinica 2006 Apr

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To isolate triterpene saponins of polygalacic acid type from the roots of Platycodon grandiflorum (Jacq.) A. DC and to identify their structures. The compounds were separated by means of extraction, chromatography on silica gel, MPLC and HPLC, and their structures were elucidated on the basis of spectral analyses (FAB-MS, IR, 1H NMR, 13C NMR etc.). Three triterpene saponins were isolated from the roots of Platycodon grandiflorum. They were identified as 3-O-beta-D-laminaribiosyl polygalacic acid (I), 3-O-beta-D-glucopyranosyl polygalacic acid (II), polygalacin D (III), separately. Compound I is a new compound, compounds II, III are known triterpene saponins. The compound I and II were isolated from the plant for the first time, which is also the monodesmoside from the plant for the first time.

Citation

Wen-wei Fu, Wen-bin Hou, De-qiang Dou, Hui-ming Hua, Mao-hua Gui, Rui Fu, Ying-jie Chen, Yue-hu Pei. Saponins of polygalacic acid type from Platycodon grandiflorum]. Yao xue xue bao = Acta pharmaceutica Sinica. 2006 Apr;41(4):358-60