Cysteine proteinase inhibitors in murine cysticercosis.

Salman Baig, Raymond T Damian, Jorge Morales-Montor, Rupal Thazhath, Amr Ghaleb, Meredith Welch, Jamil Talhouk, A Clinton White

Department of Cellular Biology, University of Georgia, Athens, Georgia 30603, USA.

Antimicrobial agents and chemotherapy 2006 Aug

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We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.

Citation

Salman Baig, Raymond T Damian, Jorge Morales-Montor, Rupal Thazhath, Amr Ghaleb, Meredith Welch, Jamil Talhouk, A Clinton White. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrobial agents and chemotherapy. 2006 Aug;50(8):2886-8