A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers.

Belén Sádaba, Miguel A Campanero, Maria Jose Muñoz-Juarez, Isabel Gil-Aldea, Emilio García-Quetglas, Antonio Esteras, Jose R Azanza

Clinical Research Unit, Clínica Universitaria de Navarra, Universidad de Navarra, 31008, Pamplona, Spain. bsadaba@unav.es

European journal of clinical pharmacology 2006 Oct

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Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly. The primary objective of this study was to compare the 12-h pharmacokinetic profile of S(+)-ibuprofen following administration of single doses of ibuprofen arginate (600 mg) and dexibuprofen (400 mg) in healthy volunteers. Twenty-four volunteers were recruited into an open-label, randomised, two-period, single-centre study with crossover design. Both treatments were well tolerated. Ibuprofen arginate and dexibuprofen showed similar bioavailability for S(+)-ibuprofen. Compared with dexibuprofen, ibuprofen arginate demonstrated a 45% higher maximum concentration (C(max)), and a time to peak concentration (T(max)) 2 h sooner. Ibuprofen arginate approaches maximum concentrations of S(+)-ibuprofen faster and higher than dexibuprofen.

Citation

Belén Sádaba, Miguel A Campanero, Maria Jose Muñoz-Juarez, Isabel Gil-Aldea, Emilio García-Quetglas, Antonio Esteras, Jose R Azanza. A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers. European journal of clinical pharmacology. 2006 Oct;62(10):849-54