Effect of drug type on the degradation rate of PLGA matrices.

Steven J Siegel, Jonathan B Kahn, Kayla Metzger, Karen I Winey, Kathryn Werner, Nily Dan

Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2006 Nov

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We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate.

Citation

Steven J Siegel, Jonathan B Kahn, Kayla Metzger, Karen I Winey, Kathryn Werner, Nily Dan. Effect of drug type on the degradation rate of PLGA matrices. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. 2006 Nov;64(3):287-93