EG-1 interacts with c-Src and activates its signaling pathway.

Ming Lu, Liping Zhang, Maryam R Sartippour, Andrew J Norris, Mai N Brooks

Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA.

International journal of oncology 2006 Oct

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EG-1 is significantly elevated in breast, colorectal, and prostate cancers. Overexpression of EG-1 stimulates cellular proliferation, and targeted inhibition blocks mouse xenograft tumor growth. To further clarify the function of EG-1, we investigated its role in c-Src activation. We observed that EG-1 overexpression results in activation of c-Src, but found no evidence that EG-1 is a direct Src substrate. EG-1 also binds to other members of the Src family. Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation.

Citation

Ming Lu, Liping Zhang, Maryam R Sartippour, Andrew J Norris, Mai N Brooks. EG-1 interacts with c-Src and activates its signaling pathway. International journal of oncology. 2006 Oct;29(4):1013-8