Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

Lisa Y Chiang, Daniele E Ejzykowicz, Zong-Qiang Tian, Leonard Katz, Scott G Filler

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

Antimicrobial agents and chemotherapy 2006 Oct

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Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

Citation

Lisa Y Chiang, Daniele E Ejzykowicz, Zong-Qiang Tian, Leonard Katz, Scott G Filler. Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy. 2006 Oct;50(10):3464-6