Boric acid and boronic acids inhibition of pigeonpea urease.

K Ravi Charan Reddy, Arvind M Kayastha

School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.

Journal of enzyme inhibition and medicinal chemistry 2006 Aug

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Urease from the seeds of pigeonpea was competitively inhibited by boric acid, butylboronic acid, phenylboronic acid, and 4-bromophenylboronic acid; 4-bromophenylboronic acid being the strongest inhibitor, followed by boric acid > butylboronic acid > phenylboronic acid, respectively. Urease inhibition by boric acid is maximal at acidic pH (5.0) and minimal at alkaline pH (10.0), i.e., the trigonal planar B(OH)3 form is a more effective inhibitor than the tetrahedral B(OH)4 -anionic form. Similarly, the anionic form of phenylboronic acid was least inhibiting in nature.

Citation

K Ravi Charan Reddy, Arvind M Kayastha. Boric acid and boronic acids inhibition of pigeonpea urease. Journal of enzyme inhibition and medicinal chemistry. 2006 Aug;21(4):467-70