A synthesis of the welwistatin core.

Ryan Lauchli, Kenneth J Shea

Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, California 92697-2025, USA.

Organic letters 2006 Nov 9

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Structure: see text] An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels-Alder reaction, with indole serving as the tether between diene and dienophile, to form the natural product's characteristic bicyclo[4.3.1]decane skeleton.