D-elg, a member of the Drosophila ets gene family: sequence, expression and evolutionary comparison.

L J Pribyl, D K Watson, R A Schulz, T S Papas

Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702-1201.

Oncogene 1991 Jul

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We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage embryos, prior to transcriptional activation of the zygotic genome, and is maintained throughout embryogenesis with no regional localization. The cDNA encodes a predicted protein of 15.4kD that has an 86 amino acid sequence with 72% similarity to the carboxy terminal region of the Drosophila ets-2 gene. Comparison with all known ets genes allows us to define a minimal region required for assignment to the ets gene family.

Citation

L J Pribyl, D K Watson, R A Schulz, T S Papas. D-elg, a member of the Drosophila ets gene family: sequence, expression and evolutionary comparison. Oncogene. 1991 Jul;6(7):1175-83