Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H, 3H, 6H, 8H)-tetraone as a novel universal base.

Masanori Kataoka, Taisuke Hirano, Kenji Kuroda, Yoshihiro Hayakawa

Research Center for Computational Science, National Institutes for Natural Sciences, Okazaki 444-8787, Japan.

Nucleic acids symposium series (2004) 2005

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A derivative of pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT), which may form various keto-enol tautomers suitable for forming base pairs with all natural bases, and is thus expected to serve as a universal base, was synthesized. The ability of PPT to form base pairs with natural bases was evaluated by UV analysis.

Citation

Masanori Kataoka, Taisuke Hirano, Kenji Kuroda, Yoshihiro Hayakawa. Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H, 3H, 6H, 8H)-tetraone as a novel universal base. Nucleic acids symposium series (2004). 2005(49):119-20