A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.

Kenji Kuroda, Hidehiko Kodama, Masanori Kataoka, Yoshihiro Hayakawa

Graduate School of Information Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan.

Nucleic acids symposium series (2004) 2006

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A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone, which is expected to serve as a universal base, was synthesized and binding affinity of this artificial nucleoside to natural nucleosides was investigated by UV analysis. As the result, it was revealed that the artificial derivative universally forms a base pair with four kinds of natural deoxyribonucleosides.

Citation

Kenji Kuroda, Hidehiko Kodama, Masanori Kataoka, Yoshihiro Hayakawa. A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides. Nucleic acids symposium series (2004). 2006(50):17-8