Nina M van Sorge, Nobuhiro Yuki, Marc D Jansen, Yukihiro Nishimoto, Keiichiro Susuki, John H J Wokke, Jan G J van de Winkel, Leonard H van den Berg, W-Ludo van der Pol
Department of Immunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
Journal of neuroimmunology 2007 JanAcute motor axonal neuropathy (AMAN) in humans is associated with the presence of GM1-specific antibodies. Immunization of rabbits with GM1-containing ganglioside mixtures, purified GM1, or Campylobacter jejuni lipo-oligosaccharide exhibiting a GM1-like structure elicits GM1-specific antibodies, but axonal polyneuropathy only occurs in a subset of animals. This study aimed to dissect the molecular basis for the variable induction of AMAN in rabbits. Therefore, we analyzed the pro-inflammatory characteristics of GM1-specific antibodies in plasma samples from ganglioside-immunized rabbits with and without neurological deficits. GM1-specific plasma samples from all rabbits with AMAN were capable of activating both complement and leukocytes, in contrast to none of the plasma samples from rabbits without paralysis. Furthermore, GM1-specific IgG-mediated activation of leukocytes was detected before the onset of clinical signs. These data suggest that AMAN only occurs in rabbits that develop GM1-specific antibodies with pro-inflammatory properties.
Nina M van Sorge, Nobuhiro Yuki, Marc D Jansen, Yukihiro Nishimoto, Keiichiro Susuki, John H J Wokke, Jan G J van de Winkel, Leonard H van den Berg, W-Ludo van der Pol. Leukocyte and complement activation by GM1-specific antibodies is associated with acute motor axonal neuropathy in rabbits. Journal of neuroimmunology. 2007 Jan;182(1-2):116-23
PMID: 17161468
View Full Text