Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour.

The Celastrus oil, extracted from seeds of Celastrus paniculatus tested at 2 dose levels (1 and 1.5 g/kg), exhibited significant anxiolytic activity and did not produce tolerance. The non-sedative nature and reversal of buspirone induced behaviour (in open field exploration) point to the serotonergic mechanism underlying the anxiolysis, inspiring further research.

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Ramamoorthy Rajkumar, Elavarasan Prem Kumar, Suresh Sudha, Bhojraj Suresh. Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour. Fitoterapia. 2007 Feb;78(2):120-4

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PMID: 17169502

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