Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion.

F A A Gondim, E A De Sousa, N Latov, H W Sander, R L Chin, T H Brannagan

Department of Neurology, Weill Medical College of Cornell University, New York, NY, USA.

Journal of neurology, neurosurgery, and psychiatry 2007 Aug

filter terms:

Patients with anti-myelin associated glycoprotein (anti-MAG) neuropathy have uniform slowing without temporal dispersion, but do usually have disproportionately distal slowing. We evaluated distal compound muscle action potential (CMAP) dispersion in 29 patients with anti-MAG/sulphated glucuronyl paragloboside (SGPG) neuropathy (titres > or = 12,800). Among 138 motor responses, 15% (tibial), 7.3% (peroneal), 10.7% (median) and 13.8% (ulnar) had distal CMAP duration > 9 ms. Disproportionate distal slowing with normal distal CMAP duration in the arms may be useful to differentiate chronic inflammatory demyelinating polyneuropathy from anti-MAG/SGPG associated neuropathy.

Citation

F A A Gondim, E A De Sousa, N Latov, H W Sander, R L Chin, T H Brannagan. Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion. Journal of neurology, neurosurgery, and psychiatry. 2007 Aug;78(8):902-4