Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives.

A R Khomutov, N A Grigorenko, S G Skuridin

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St, 32, Moscow, Russia. alexkhom@list.ru

Biochemical Society transactions 2007 Apr

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The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu(2+) ions, as well as novel N(1)- and N(12)-Ac-SpmTriens and bis-Et-SpmTrien (N(1),N(12)-diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed.

Citation

A R Khomutov, N A Grigorenko, S G Skuridin. Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives. Biochemical Society transactions. 2007 Apr;35(Pt 2):369-73