Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females.

Jian Zhao, Dong-Hai Xiong, Yan Guo, Tie-Lin Yang, Robert R Recker, Hong-Wen Deng

The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China.

Human reproduction (Oxford, England) 2007 Jun

filter terms:

The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test. Significant association (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected. Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.

Citation

Jian Zhao, Dong-Hai Xiong, Yan Guo, Tie-Lin Yang, Robert R Recker, Hong-Wen Deng. Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females. Human reproduction (Oxford, England). 2007 Jun;22(6):1789-94