Arrested replication fork processing: interplay between checkpoints and recombination.

Sarah Lambert, Benoît Froget, Antony M Carr

DNA repair 2007 Jul 01

filter terms:

The arrest of DNA replication by DNA damage, nucleotide depletion, DNA-protein complexes or following clashes between transcription and replication factors all have the capacity to promote genome instability. In this review, we discuss how DNA replication is regulated by the checkpoint pathways that stabilise arrested replication forks and the recombination factors that process specific DNA structures resulting from fork arrest. We examine what is known about the interplay between the checkpoints and the recombination apparatus and review the evidence for a recombination-based fork restart pathway in eukaryotes.

Citation

Sarah Lambert, Benoît Froget, Antony M Carr. Arrested replication fork processing: interplay between checkpoints and recombination. DNA repair. 2007 Jul 01;6(7):1042-61