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To describe the occurrence of erosive arthropathy in systemic lupus erythematosus (SLE) and its relationship to anti-CCP antibodies. Retrospective medical record review of a case series of five female patients with SLE and erosive arthropathies. The initial disease presentation in all patients was a polyarthritis. Anti-CCP antibodies were detected in 4 out of 5 (80%) patients, 2 of whom had a positive rheumatoid factor. Erosive arthritis was strongly associated with the presence of anti-CCP antibodies in these patients with SLE, who presented with polyarthritis. Anti-CCP in patients with SLE may be a marker of a more severe joint disease.


J B Martinez, J S Valero, A J Bautista, J F Restrepo, E L Matteson, F Rondon, A Iglesias-Gamarra. Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clinical and experimental rheumatology. 2007 Jan-Feb;25(1):47-53

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PMID: 17417990

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