Stromal-cell regulation of natural killer cell differentiation.

Claude Roth, Carla Rothlin, Sylvain Riou, David H Raulet, Greg Lemke

Laboratoire Immunité Cellulaire Antivirale, Département d'Immunologie, Institut Pasteur, 75724, Paris Cedex 15, France. clroth@pasteur.fr

Journal of molecular medicine (Berlin, Germany) 2007 Oct

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Natural killer (NK) cells are bone-marrow-derived lymphocytes that play a crucial role in host defense against some viral and bacterial infections, as well as against tumors. Their phenotypic and functional maturation requires intimate interactions between the bone marrow stroma and committed precursors. In parallel to the identification of several phenotypic and functional stages of NK cell development, recent studies have shed new light on the role of stromal cells in driving functional maturation of NK cells. In this review, we provide an overview of the role of bone marrow microenvironment in NK cell differentiation.

Citation

Claude Roth, Carla Rothlin, Sylvain Riou, David H Raulet, Greg Lemke. Stromal-cell regulation of natural killer cell differentiation. Journal of molecular medicine (Berlin, Germany). 2007 Oct;85(10):1047-56