Difructose anhydride III promotes absorption of the soluble flavonoid alphaG-rutin in rats.

Megumi Matsumoto, Noriko Matsukawa, Hideyuki Chiji, Hiroshi Hara

Department of Food Science and Human Nutrition, Faculty of Human Life Science, Fuji Women's University, Ishikari, Hokkaido 061-3204, Japan.

Journal of agricultural and food chemistry 2007 May 16

filter terms:

A highly soluble quercetin glycoside, alphaG-rutin, is a glucose adduct of insoluble rutin. We examined the effects of difructose anhydride III (DFAIII; di-D-fructofuranosyl 1,2':2,3'-dianhydride) on intestinal absorption of alphaG-rutin by rat experiments. alphaG-rutin, rutin, quercetin, and the quercetin conjugate appeared in the portal blood after an intubation of alphaG-rutin (100 micromol), DFAIII effected higher portal concentrations of alphaG-rutin in portal cannulated rats. In ligated jejunal and ileal loops of rats, alphaG-rutin, rutin, quercetin, and the quercetin conjugate appeared in the intestinal mesenteric blood at both 30 and 60 min in both loops; the concentration of alphaG-rutin was 1.5-3 times higher when absorbed in the presence DFAIII. In the isolated mucosae of the jejunum and ileum, mucosal-to-serosal passage of alphaG-rutin increased with the addition of 100 micromol of DFAIII. These results indicate that alphaG-rutin is absorbed as the intact form and that DFAIII stimulates its absorption in the small intestine.

Citation

Megumi Matsumoto, Noriko Matsukawa, Hideyuki Chiji, Hiroshi Hara. Difructose anhydride III promotes absorption of the soluble flavonoid alphaG-rutin in rats. Journal of agricultural and food chemistry. 2007 May 16;55(10):4202-8