Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
RNA (New York, N.Y.) 2007 JunThe GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3' end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3' end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.
Jae Eun Kwak, Marvin Wickens. A family of poly(U) polymerases. RNA (New York, N.Y.). 2007 Jun;13(6):860-7
PMID: 17449726
View Full Text