The unfolded protein response and integrated stress response to anoxia.

Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 1

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The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs that are critical for tumor survival: the unfolded protein response and integrated stress response. Therefore, targeting additional components of anoxic pathways, besides the hypoxia-inducible response, may be effective for future anticancer therapies.

Citation

Tomasz Rzymski, Adrian L Harris. The unfolded protein response and integrated stress response to anoxia. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 May 1;13(9):2537-40