Identification and characterization of DUSP27, a novel dual-specific protein phosphatase.

Ilan Friedberg, Konstantina Nika, Lutz Tautz, Kan Saito, Fabio Cerignoli, Iddo Friedberg, Adam Godzik, Tomas Mustelin

FEBS letters 2007 May 29

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A novel human dual-specific protein phosphatase (DSP), designated DUSP27, is here described. The DUSP27 gene contains three exons, rather than the predicted 4-14 exons, and encodes a 220 amino acid protein. DUSP27 is structurally similar to other small DSPs, like VHR and DUSP13. The location of DUSP27 on chromosome 10q22, 50kb upstream of DUSP13, suggests that these two genes arose by gene duplication. DUSP27 is an active enzyme, and its kinetic parameters and were determined. DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.

Citation

Ilan Friedberg, Konstantina Nika, Lutz Tautz, Kan Saito, Fabio Cerignoli, Iddo Friedberg, Adam Godzik, Tomas Mustelin. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS letters. 2007 May 29;581(13):2527-33