TGFbeta signalling in control of T-cell-mediated self-reactivity.

Yuri P Rubtsov, Alexander Y Rudensky

Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA.

Nature reviews. Immunology 2007 Jun

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In the immune system, transforming growth factor-beta (TGFbeta) affects multiple cell lineages by either promoting or opposing their differentiation, survival and proliferation. Understanding the cellular mechanisms of TGFbeta-mediated regulation is complicated due to a broad distribution of TGFbeta receptors on the surface of different immune-cell types. Recent studies using in vivo genetic approaches revealed a critical role for TGFbeta signalling in T cells in restraining fatal autoimmune lesions. Here, we review recent advances in our understanding of a role for TGFbeta signalling in the regulation of T-cell differentiation in the thymus and in the periphery, with a particular emphasis on TGFbeta-mediated control of self-reactive T cells.

Citation

Yuri P Rubtsov, Alexander Y Rudensky. TGFbeta signalling in control of T-cell-mediated self-reactivity. Nature reviews. Immunology. 2007 Jun;7(6):443-53