Bioactive polyketides from Peperomia duclouxii.

Na Li, Jian-lin Wu, Toshiaki Hasegawa, Jun-ichi Sakai, Li-ming Bai, Li-yan Wang, Saori Kakuta, Yumiko Furuya, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando

National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. nali9898@hotmail.com

Journal of natural products 2007 Jun

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Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 microg/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 microg/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1alpha or TNF-alpha.

Citation

Na Li, Jian-lin Wu, Toshiaki Hasegawa, Jun-ichi Sakai, Li-ming Bai, Li-yan Wang, Saori Kakuta, Yumiko Furuya, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando. Bioactive polyketides from Peperomia duclouxii. Journal of natural products. 2007 Jun;70(6):998-1001