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Progesterone is an essential hormone for pregnancy maintenance. This hormone acts by binding to its intracellular receptor or by rapid non-genomic actions to regulate a wide variety of biological functions in the feto-placental unit. Progesterone regulates blastocyst implantation and placental development by inducing immunosuppression through type Th2 cytokines secretion. This review summarizes current research about the role of progesterone as critical regulator of expression and secretion of cytokines by T-cell and other placental cells.


David Barrera, Euclides Avila, Lorenza Díaz. Immunological role of progesterone in the maintenance of pregnancy]. Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición. 2007 Mar-Apr;59(2):139-45

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PMID: 17633802

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