Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration.

Yuqing Wan, Gang Feng, Francis H Shen, Gary Balian, Cato T Laurencin, Xudong Li

Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

Macromolecular bioscience 2007 Nov 12

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A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octanediol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased with the extension of the polymerization time, while the degradation rate decreased. Rat AF cells proliferated on the POM films and maintained their phenotype. The 3D scaffold also supported the growth of the AF cells, as confirmed by Safranin-O and type II collagen staining. POM also demonstrated a good biocompatibility in an in vivo foreign body response assay, an important prerequisite for tissue engineering applications. This study suggests that elastic POM scaffold may be an ideal candidate for AF tissue engineering.

Citation

Yuqing Wan, Gang Feng, Francis H Shen, Gary Balian, Cato T Laurencin, Xudong Li. Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration. Macromolecular bioscience. 2007 Nov 12;7(11):1217-24