The antifungal polyketide ambruticin targets the HOG pathway.

Leandro Vetcher, Hugo G Menzella, Toshiaki Kudo, Takayuki Motoyama, Leonard Katz

Kosan Biosciences Inc, Hayward, CA 94545, USA.

Antimicrobial agents and chemotherapy 2007 Oct

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The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

Citation

Leandro Vetcher, Hugo G Menzella, Toshiaki Kudo, Takayuki Motoyama, Leonard Katz. The antifungal polyketide ambruticin targets the HOG pathway. Antimicrobial agents and chemotherapy. 2007 Oct;51(10):3734-6