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Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.

Citation

Aina Colombo, Natalia De la Figuera, Joan Carles Fernàndez, Dolors Fernández-Forner, Fernando Albericio, Pilar Forns. A nonacid degradable linker for solid-phase synthesis. Organic letters. 2007 Oct 11;9(21):4319-22

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PMID: 17867699

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