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Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.


Aina Colombo, Natalia De la Figuera, Joan Carles Fernàndez, Dolors Fernández-Forner, Fernando Albericio, Pilar Forns. A nonacid degradable linker for solid-phase synthesis. Organic letters. 2007 Oct 11;9(21):4319-22

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PMID: 17867699

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