Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system.

Yun-jing Luo, Tai-feng Lin, Shu-fen Zhang, Rui Liu, Ru-gang Zhong

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. luoyj@bjut.edu.cn

Journal of environmental sciences (China) 2007

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The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzo[a]pyrene (B[a]P) metabolism. Three model systems consisting of different iron porphyrins were compared, and the results showed that the peroxynitrite/T(p-Cl)PPFeCl system was the highest catalytic efficiency in the metabolism of B[a]P. We analyzed the B[a]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzo[a]pyrenes which are the special metabolites of B[a]P induced by peroxynitrite.

Citation

Yun-jing Luo, Tai-feng Lin, Shu-fen Zhang, Rui Liu, Ru-gang Zhong. Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system. Journal of environmental sciences (China). 2007;19(4):385-6