A constant affinity threshold for T cell tolerance.

Dieter Naeher, Mark A Daniels, Barbara Hausmann, Philippe Guillaume, Immanuel Luescher, Ed Palmer

The Journal of experimental medicine 2007 Oct 29

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T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes.

Citation

Dieter Naeher, Mark A Daniels, Barbara Hausmann, Philippe Guillaume, Immanuel Luescher, Ed Palmer. A constant affinity threshold for T cell tolerance. The Journal of experimental medicine. 2007 Oct 29;204(11):2553-9