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The endogenous ligand for growth-hormone secretagogue receptor (GHS-R) was purified from the stomach and named it "ghrelin," after the word root "ghre" in Proto-Indo-European languages meaning "grow", since ghrelin has potent growth hormone (GH) releasing activity. Ghrelin plays important roles for maintaining growth hormone release and energy homeostasis in vertebrates. In this essay, I described my personal memory on the discovery of ghrelin in the year 1999.

Citation

Masayasu Kojima. The discovery of ghrelin--a personal memory. Regulatory peptides. 2008 Jan 10;145(1-3):2-6

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PMID: 17942169

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