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An unprecedented 24-N-imidazolyl steroidal alkaloid, amaranzole A, was isolated from a tropical sponge, Phorbas amaranthus. The structure was solved by interpretation of MS, NMR, including a novel exciton-coupled CD spectrum due to an allyl imidazole, and comparison with model compounds.

Citation

Brandon I Morinaka, Makoto N Masuno, Joseph R Pawlik, Tadeusz F Molinski. Amaranzole A, a new N-imidazolyl steroid from Phorbas amaranthus. Organic letters. 2007 Dec 6;9(25):5219-22

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PMID: 17990891

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