Pharmacology of neurotransmitter transport into secretory vesicles.

Farrukh A Chaudhry, Jean-Luc Boulland, Monica Jenstad, May K L Bredahl, Robert H Edwards

The Biotechnology Centre of Oslo, University of Oslo, 1125, Blindern, Oslo, 0317, Norway. f.a.chaudhry@biotek.uio.no

Handbook of experimental pharmacology 2008

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Many neuropsychiatric disorders appear to involve a disturbance of chemical neurotransmission, and the mechanism of available therapeutic agents supports this impression. Postsynaptic receptors have received considerable attention as drug targets, but some of the most successful agents influence presynaptic processes, in particular neurotransmitter reuptake. The pharmacological potential of many other presynaptic elements, and in particular the machinery responsible for loading transmitter into vesicles, has received only limited attention. The similarity of vesicular transporters to bacterial drug resistance proteins and the increasing evidence for regulation of vesicle filling and recycling suggest that the pharmacological potential of vesicular transporters has been underestimated. In this review, we discuss the pharmacological effects of psychostimulants and therapeutic agents on transmitter release.

Citation

Farrukh A Chaudhry, Jean-Luc Boulland, Monica Jenstad, May K L Bredahl, Robert H Edwards. Pharmacology of neurotransmitter transport into secretory vesicles. Handbook of experimental pharmacology. 2008(184):77-106