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2 ',3 '-Isopropylidene group can be used as a molecular scaffold for the introduction of modifications at 5 ' and 1 ' positions of adenosine and these modified nucleosides are used to evaluate the biocatalytic activity of adenosine and adenylate deaminase.


Pierangela Ciuffreda, Laura Alessandrini, Enzo Santaniello. 2',3'-isopropylidene group, a molecular scaffold to study the activity of adenosine and adenylate deaminase on adenosine analogues modified in the ribose moiety. Nucleosides, nucleotides & nucleic acids. 2007;26(10-12):1311-3

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PMID: 18066774

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