Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea.

Dong Soo Kim, Taek Jin Lee, Jin Han Kang, Jong-Hyun Kim, Jung Hyun Lee, Sang Hyuk Ma, Sun Young Kim, Hwang Min Kim, Son Mun Shin

Department of Pediatrics, Yonsei University College of Medicine, Severance Chilfren's Hospital, Seoul, South Korea. dskim6634@yumc.yonsei.ac.kr

The Pediatric infectious disease journal 2008 Feb

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We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.

Citation

Dong Soo Kim, Taek Jin Lee, Jin Han Kang, Jong-Hyun Kim, Jung Hyun Lee, Sang Hyuk Ma, Sun Young Kim, Hwang Min Kim, Son Mun Shin. Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea. The Pediatric infectious disease journal. 2008 Feb;27(2):177-8